Autonomic dysreflexia related to intradetrusor injections of BOTOX could take place in people handled for detrusor overactivity connected with a neurologic affliction and should call for prompt professional medical therapy.
Individuals treated with botulinum toxin may well have to have quick healthcare awareness should they develop issues with swallowing, speech or respiratory Conditions. These reactions can occur inside several hours to months soon after injection with botulinum toxin [see ADVERSE REACTIONS].
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The information reflect The share of people whose examination final results were considered positive for antibodies to MYOBLOC in each an in vitro and in vivo assay. The final results of these antibody tests are very depending on the sensitivity and specificity with the assays.
These complications could make it unsafe so that you can generate a car or do other risky things to do. See "What should really I steer clear of when getting MYOBLOC?"
Immunogenicity possible was not even more evaluated for MYOBLOC in the therapy of chronic sialorrhea.
Not many patients age 75 or older were being enrolled; hence, no conclusions regarding the security and efficacy of MYOBLOC in this age team is often established.
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Individuals with neuromuscular disorders can be at enhanced danger of clinically sizeable consequences which include critical dysphagia and respiratory compromise from regular doses of MYOBLOC [see ADVERSE REACTIONS].
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In addition, the observed incidence of antibody positivity within an myobloc injection assay could be influenced by several elements which includes sample handling, concomitant remedies, and underlying disease. For these motives, comparison on the incidence of antibodies to MYOBLOC Along with the incidence of antibodies to other items might be misleading.
The potency models of MYOBLOC are unique to your planning and assay technique used. They don't seem to be interchangeable with other preparations of botulinum toxin solutions and cannot be when compared with or converted into units of any other botulinum toxin solutions [see WARNINGS AND PRECAUTIONS, DESCRIPTION].